The topic of pH as an important, underlying systemic factor in health and disease may be new to some readers. While the role of pH is well recognized in the regulation of blood chemistry and in certain progressed pathological states of acidosis or alkalosis, it has recently been the subject of increasing interest and investigation.  

For those who wish to examine some of the published articles on physiological and cellular pH, a partial list is included below.  You may also search the topic yourself on PubMed or Google Scholar.

 

"Excess diet-derived acid titrates bone and leads to increased urinary calcium"

Deanna M. Minich, Ph.D., FACN, CNS, Jeffrey S. Bland, Ph.D., FACN, " ACID-ALKALINE BALANCE: ROLE IN CHRONIC DISEASE AND DETOXIFICATION"


"Evidence exists that a more acidic diet is detrimental to bone health" Urine pH is an indicator of dietary acid–base load, fruit and vegetables and meat intakes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk population study.

Welch, AA, et al. British Journal of Nutrition (2008), 99, 1335–1343


"In conclusion, the increasing dietary acid load in the contemporary diet can lead to the disruption in acid-alkaline homeostasis in various body compartments and eventually result in chronic disease through repeated borrowing of the body's alkaline reserves."  

Altern Ther Health Med. 2007 Jul-Aug;13(4):62-5. PMID: 1765814


"The pathobiochemical effects of chronic latent acidosis can be osteoporosis, diabetes mellitus, hyperuricemia, gout, or restricted renal function..."

Minerva Binecol. 2010 Apr;62(2):85-90. PMID 20502420


"The processes of metabolism generate hydrogen ions. Small amounts (40-80 mmol/24h) are formed from the oxidation of amino acids and the anerobic metabolism of glucose to lactic and pyruvic acid. Far more acid is produced as a result of carbon dioxide release from oxidative )aerobic) metabolism - 15,000 mmol/24h (15 x 103 mmol/24h)" 

Drage, D & Wilkinson, D. Update in Anesthesia Pharmacology, Issue 13 (2001) Article 12: 1-3

 

"But there is growing evidence that extracellular acidity per se boosts the invasiveness and metastatic capacity of cancer cells; moreover, this acidity renders cancer cells relatively resistant to the high proportion of chemotherapeutic drugs that are mildly basic, and may impede immune rejection of tumors. Thus, practical strategies for raising the extracellular pH of tumors may have therapeutic utility. In rodents, oral administration of sodium bicarbonate can raise the extracellular pH of tumors, an effect associated with inhibition of metastasis and improved responsiveness to certain cytotoxic agents; clinical appliction of this strategy appears feasible."

AlternMed Rev. 2010 Sep;15(3):264-72.


"Consequent reduction of tumor acid concentrations signficantly reduces tumor growth and invasion without altering the pH of blood or normal tissues"

Silva AS, Yunes JA, Gilles RJ, Gatenby RA. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion.  Cancer Res. 2009 Mar 15;69(6):2677-84.

 


"Bicarbonate increases tumor pH and inhibits spontaneous metastases."

Robey, IF, Baggett BK, Kirkpatrick ND, Roe DJ, et al. Cancer Res. 2009 Mar 15;69(6):2260-8 

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